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Coronary Circulation01:21

Coronary Circulation

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The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
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Fetal Circulation01:14

Fetal Circulation

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
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Multiple Allele Traits01:49

Multiple Allele Traits

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The Concept of Multiple Allelism
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Reducing Line Loss01:18

Reducing Line Loss

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In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
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Levels of Organization01:09

Levels of Organization

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Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
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Leveling Effect01:29

Leveling Effect

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In acid-base chemistry, the leveling effect refers to the limitation imposed by the solvent on the strength of acids and bases in solution. When a base stronger than the solvent's conjugate base is used, it deprotonates the solvent until the base is entirely consumed, making it ineffective against weaker acids. Conversely, an acid stronger than the solvent's conjugate acid protonates the solvent until the acid is depleted, rendering it ineffective against weaker bases. Essentially, the...
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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多発性硬化症患者における機能的トレーニングによる循環インドール-3-乳酸レベル低下の軽減

Tiffany Wences Chirino1, Frederike Adammek1, Sergen Belen1,2

  • 1Sports Medicine Research Group, Institute for Sport and Sport Science, TU Dortmund University, Dortmund, Germany.

Acta physiologica (Oxford, England)
|January 28, 2026
PubMed
まとめ
この要約は機械生成です。

定期的な運動と10週間のマルチモーダルトレーニングプログラムは、多発性硬化症患者のインドール-3-乳酸/インドール-3-酢酸指数を大幅に改善した。単回の運動セッションもインドール-3-乳酸レベルを上昇させ、神経保護効果を示唆している。

キーワード:
運動腸内細菌叢インドール多発性硬化症トリプトファン

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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科学分野:

  • 神経科学
  • 微生物学
  • 免疫学

背景:

  • インドールは、トリプトファン由来の腸内細菌叢代謝物であり、多発性硬化症（MS）における腸-脳相関に影響を与える。
  • インドール-3-乳酸（ILA）はMS患者で減少し、動物モデルでは抗炎症作用、再髄鞘化作用を示す。
  • ILAとインドール-3-酢酸（IAA）の比（ILA/IAA）は、運動や食事によって変化する神経保護指数として機能する。

主な方法:

  • 31人のRRMS患者を対象としたランダム化比較試験の二次解析。
  • ベースライン時、10週間の介入後、および一致させた健常対照群との血清インドール濃度（LC-MS/MSで測定）の比較。
  • トレーニングセッションの前、中、直後の採血による急激な運動効果の評価。

結論:

  • 10週間のマルチモーダル機能トレーニングプログラムは、RRMS患者のILA/IAA指数を改善し、腸内細菌叢における神経保護的なシフトを示唆した。
  • 急性の運動は、循環ILAレベルを急速に増加させることができる。
  • 運動介入は、MSにおける腸内細菌叢代謝物の調節と神経保護のサポートに有望である。