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rabindra.tharu.np@gmail.com
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Effects of acute hippocampal stimulation in the nonhuman primate penicillin model of temporal lobe seizures
Asynchronous distributed multielectrode stimulation (ADMES) is a novel approach to deep brain stimulation for medication resistant temporal lobe epilepsy that has shown promise in rodent and seizure models. To further evaluate its effects on a pre-clinical model, we characterized the effect of unilateral ADMES in an NHP model of temporal lobe seizures induced by intra-hippocampal…
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rabindra.tharu.np@gmail.com
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Long-range linkage disequilibrium events on the genome of dromedary camels as a signal of epistatic and directional positive selection
The genome of dromedary camels has been subjected to various evolutionary forces, such as genetic admixture, natural positive selection, and epistatic selection. These forces are considered as main factors associated with the formation of long-range linkage disequilibrium (LRLD) events. We have analyzed whole-genome data of 56 dromedary camel samples from different geographical regions across the…
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rabindra.tharu.np@gmail.com
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Deciphering the role of ferroptosis in rheumatoid arthritis: Synovial transcriptome analysis and immune infiltration correlation
The pathogenesis of rheumatoid arthritis (RA) remains elusive. The initiation of joint degeneration is characterized by the loss of self-tolerance in peripheral joints. Ferroptosis, a form of regulated cell death, holds significant importance in the pathophysiology of inflammatory arthritis, primarily due to iron accumulation and the subsequent lipid peroxidation. The present study investigated the association…
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rabindra.tharu.np@gmail.com
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Characterization of the in vitro metabolic profile of nazartinib in HLMs using UPLC-MS/MS method: In silico metabolic lability and DEREK structural alerts screening using StarDrop software
The orally given, irreversible, third-generation inhibitor of the epidermal growth factor receptor (EGFR), known as Nazartinib (EGF816), is now undergoing investigation in Phase II clinical trials conducted by Novartis for Non-Small Cell Lung Cancer. The primary aim of the current research was to establish a rapid, specific, environmentally friendly, and highly versatile UPLC-MS/MS methodology for…
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rabindra.tharu.np@gmail.com
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Failure analysis in predictive maintenance: Belt drive diagnostics with expert systems and Taguchi method for unconventional vibration features
Predictive maintenance to avoid fatigue and failure enhances the reliability of mechanics, herewith, this paper explores vibrational time-domain data in advancing fault diagnosis of predictive maintenance. This study leveraged a belt-drive system with the properties: operating rotational speeds of 500-2000 RPM, belt pretensions at 70 and 150 N, and three operational cases of healthy, faulty and…
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rabindra.tharu.np@gmail.com
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Celastrol induces ferroptosis by suppressing RRM2 in hepatocellular carcinoma
INTRODUCTION AND OBJECTIVES Ferroptosis is a novel form of cell death driven by iron dependence and lipid peroxidation, presenting a promising potential as an innovative strategy for cancer treatment. Celastrol (Cel) is particularly effective in inducing ferroptosis, but its molecular mechanism remains unclear. The study aims to elucidate the potential mechanism through both in vitro…
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rabindra.tharu.np@gmail.com
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Forecasting of flash flood susceptibility mapping using random forest regression model and geographic information systems
Flash floods, rapid and devastating inundations of water, are increasingly linked to the intensifying effects of climate change, posing significant challenges for both vulnerable communities and sustainable environmental management. The primary goal of this research is to investigate and predict a Flood Susceptibility Map (FSM) for the Ibaraki prefecture in Japan. This research utilizes a…
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rabindra.tharu.np@gmail.com
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Effects of resveratrol on biochemical and structural outcomes in osteoarthritis: A systematic review and meta-analysis of preclinical studies
BACKGROUND AND OBJECTIVE Osteoarthritis (OA) is the most common age-related disease of joints with increasing global prevalence. Persistent inflammation within the joint space is speculated to be the cause of OA. Resveratrol is an anti-inflammatory and antioxidant compound which can influence cartilage metabolism through multiple signalling pathways. This systematic review and meta-analysis aimed to summarize…
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rabindra.tharu.np@gmail.com
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IL-34 and its receptors as predictors of brain metastasis and prognosis in lung adenocarcinoma: Unveiling insights through bioinformatic and immunohistochemical investigations
BACKGROUND Brain metastasis (BM) is a prevalent form of metastasis in lung adenocarcinoma (LUAD), necessitating investigations into the underlying mechanisms. Interleukin 34 (IL-34) and its receptors, macrophage colony-stimulating factor-1 receptor (CSF-IR), Syndecan-1 (SDC-1), and protein-tyrosine phosphatase zeta receptor (PTPRZ1), are known to play pivotal roles in the metastasis of malignant tumors, thereby holding promise as…
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rabindra.tharu.np@gmail.com
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Optimizing flood predictions by integrating LSTM and physical-based models with mixed historical and simulated data
The current flood forecasting models heavily rely on historical measured data, which is often insufficient for robust predictions due to practical challenges such as high measurement costs and data scarcity. This study introduces a novel hybrid approach that synergistically combines the outputs of traditional physical-based models with historical data to train Long Short-Term Memory (LSTM)…
