聚聚氨酸核心外微球的形成和特征
Elizabeth M Dibbern1, Farah Jean-Jacques Toublan, Kenneth S Suslick
1Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.
Journal of the American Chemical Society
|May 18, 2006
概括
研究人员开发了新的多重谷氨酸微球,用于向药物输送. 这些较小,稳定的囊泡为改善生物相容性和可生物降解材料在医学中的应用提供了潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 生物相容和生物降解的囊泡对于药物和成像剂的器官向输送至关重要.
- 之前的研究表明,蛋白质微球具有疏水性内部,可提供疏水性材料,通过蛋白质交叉连接稳定.
研究的目的:
- 开发和描述使用聚氨酸用于潜在的体内应用的新型核心外微球.
- 为了研究这些新型多重谷氨酸微球的稳定性和形成机制.
主要方法:
- 通过超声波,在略微基本的pH条件下使用聚氨酸合成了核心外微球.
- 评估了在生理条件下的粒子大小和稳定性.
主要成果:
- 与之前的基于蛋白质的微球相比,聚聚氨酸微球成功地形成了更小的尺寸.
- 这些微球在体内使用的条件下表现出稳定性.
- 微球稳定性归因于键网络,而不是共价交叉链接.
结论:
- 多聚氨酸微球代表了一种有前途的新型生物相容和可生物降解囊泡,用于药物和成像剂的输送.
- 观察到的稳定性和较小的尺寸使它们成为适合体内应用的候选者.
- 这种依赖于键的形成机制为囊稳定提供了对共价交叉链接的替代方案.
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