一个前额叶皮层-脑干神经元投影,控制对行为挑战的反应
Melissa R Warden1, Aslihan Selimbeyoglu, Julie J Mirzabekov
1Department of Bioengineering, Stanford University, Stanford, California 94305, USA. mwarden@stanford.edu
Nature
|November 20, 2012
概括
特定的中间前额叶皮层 (mPFC) 细胞投射到背部拉菲核 (DRN),因果控制活跃的行为反应. 激活这些mPFC-DRN通路在具有挑战性的情况下迅速影响行动选择.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 前额叶皮质 (PFC) 在行为控制中起着至关重要的作用,其功能障碍与冲动性或动机相关.
- 了解PFC内驱动努力行动的特定神经电路对于解决行为障碍至关重要.
研究的目的:
- 调查中部前额叶皮层 (mPFC) 电路,这些电路是对挑战积极行为反应的选择的基础.
- 在mPFC中识别特定的神经元群体,以因果关系影响行动选择和动机.
主要方法:
- 开发了一种定量方法,用于持续评估自由移动的老鼠的活跃行为反应.
- 利用单单单元电生理学和光遗传学来实时监测和操纵神经活动.
- 采用投射准光遗传学来选择性地激活具有特定下游连接的mPFC神经元.
主要成果:
- 许多mPFC神经元表现出与行动决定相关的触发模式的瞬间调节.
- 一般mPFC主要神经元的直接激活没有影响活动行为.
- 选择性激活的mPFC细胞投射到背脊拉菲核 (DRN) 深刻和可逆地改变了活跃的行为状态选择.
结论:
- 特定的mPFC亚群,由它们对DRN的预测定义,对于驱动积极的行为反应至关重要.
- 这些发现揭示了行动选择和动机的神经机制.
- 结果提供了关于正常和病理动机背后的神经回路的见解,这可能与抑郁症等疾病有关.
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