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细胞与细胞之间的相互作用防止了C. elegans中 soma和生殖系之间的潜在诱导相互作用
G Seydoux1, T Schedl, I Greenwald
1Department of Biology, Princeton University, New Jersey 08544.
Cell
|June 15, 1990
概括
在C. elegans中,细胞通常会防止生殖细胞不适当地分裂. 这项研究表明,破坏体性淋巴细胞或lin-12功能会导致细胞不适当地信号生殖细胞的增殖.
科学领域:
- 发育生物学是发展生物学.
- 细胞信号传递 细胞信号传递
- 遗传学 是一个遗传学.
背景情况:
- 在C. elegans中,生殖系干细胞被远端细胞 (DTC) 维持在线粒分裂中,并靠近进入半分裂.
- 细胞 (AC) 是发生腺体内的体细胞,在发生腺体和卵细胞发育中起作用.
研究的目的:
- 研究调节C. elegans.生殖线增殖和分化的机制.
- 为了确定细胞和遗传因素,防止体和生殖细胞之间的不适当的相互作用.
主要方法:
- 激光切除体质性淋巴细胞.
- 在C. elegans中进行马赛克分析.
- 对lin-12和glp-1突变体的遗传分析.
主要成果:
- 阴性淋巴细胞的切除或lin-12中的突变会导致近端生殖细胞核中不适当的线粒活动.
- 在这些条件下,细胞 (AC) 不恰当地向近端生殖细胞核发出信号,要求它们在线粒分裂.
- 无论是AC-germline还是DTC-germline的相互作用都需要glp-1活动.
结论:
- 通过lin-12活动,体性淋巴细胞通常会阻止AC不适当地向生殖系发出信号.
- 一个拟议的模型表明,通常在体细胞中作用于lin-12的AC信号,当lin-12缺席时,可以在生殖系激活glp-1.
- 这些发现强调了精确的细胞-细胞通信和信号通路在预防异常发育过程中的重要性.
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