调节早期转录的过渡过程.
Margaux Michel1, Patrick Cramer
1Gene Center Munich and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.
Cell
|May 28, 2013
概括
基因表达调节涉及RNA聚合酶II (PolII) 转录. 在Kouzine等人. 揭示了DNA化控制作为mRNA延长的关键速度限制步骤,影响基因调节.
科学领域:
- 分子生物学分子生物学
- 生物化学 生物化学
- 遗传学 是一个遗传学.
背景情况:
- 基因表达主要控制在RNA聚合酶II (PolII) 转录的启动阶段.
- 了解转录中的速度限制步骤对于破译基因调节至关重要.
研究的目的:
- 调查DNA融化的作用在生产性mRNA延长的速度限制步骤.
- 在转录中的更广泛的能量转换中将DNA融化控制置于背景中.
主要方法:
- 由Kouzine等人进行的研究. 很可能使用生物化学和生物物理技术来评估转录期间的DNA化动态.
- 对参与RNA聚合酶II转录的能量转换进行分析.
主要成果:
- 对DNA融化的控制被确定为生产性mRNA延长的关键速度限制步骤.
- 这一发现突出了转录过程中一个关键的监管检查点.
结论:
- 在调节mRNA生产效率方面,DNA融化动态起着关键作用.
- 这些发现为转录启动和延长的能量格局提供了新的见解.
相关概念视频
02:36RNA Polymerase II Accessory Proteins
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01:10Transcription
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
01:17Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
01:10Transcription
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
01:17Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
02:04Co-activators and Co-repressors
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