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Usp16有助于导致唐氏综合征的体质干细胞缺陷

Maddalena Adorno1, Shaheen Sikandar, Siddhartha S Mitra

  • 1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature
|September 13, 2013
PubMed
概括

在唐氏综合征模型中Usp16的三倍化损害了细胞更新,并导致过早衰老. 降低Usp16水平在很大程度上可以扭转这些缺陷,这表明Usp16是唐氏综合征病理的治疗点.

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