微生物组:关注因果关系和机制
1Department of Bioengineering and ChEM-H, Stanford University and Chan Zuckerberg Biohub, Stanford, CA 94305, USA.
Cell
|August 11, 2018
概括
微生物组领域需要转向证明因果关系和分子机制. 专注于微生物群驱动的大规模,易于测量的表型以释放其全部潜力.
科学领域:
- 微生物学
- 系统生物学
- 基因组学
背景情况:
- 微生物组领域在学术研究和工业应用方面都在显著增长.
- 目前的研究经常确定微生物群落和宿主表型之间的相关性.
- 需要超越相关性来建立明确的联系.
研究的目的:
- 倡导微生物组研究的战略重点.
- 强调建立因果关系和阐明分子机制的重要性.
- 引导未来的研究取得有影响力和可衡量的成果.
主要方法:
- 这篇视角文章回顾了微生物组研究当前的趋势和挑战.
- 它提出了一个优先考虑研究方向的框架.
- 重点是需要的实验证据类型和表型读数.
主要成果:
- 现在对微生物组研究的热情可能不会转化为可预测的应用,
- 建立因果关系需要对分子相互作用进行严格的调查.
- 优先考虑大规模,易于测量的表型对于明确的结果至关重要.
结论:
- 微生物组领域必须优先确定因果关系和分子机制以实现其潜力.
- 未来的研究应该集中在显然受到微生物群的显著影响的表型上.
- 这一战略重点将加速将微生物组发现转化为现实世界的应用.
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