组织特异性免疫对于一个不断变化的世界
Stuart P Weisberg1, Basak B Ural2, Donna L Farber3
1Department of Pathology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Cell
|March 19, 2021
概括
我们的免疫系统通过清除病原体和形成记忆细胞的T细胞来保护我们. 诸如衰老和气候变化等压力因素会影响组织免疫力,
科学领域:
- 免疫学
- 环境健康
- 老龄化研究
背景情况:
- 免疫系统,特别是T细胞,对病原体进行防御并维持组织平衡.
- 组织内存T细胞 (TRMs) 对于身体各个部位的长期免疫是至关重要的.
研究的目的:
- 讨论压力因素如何影响组织免疫反应.
- 提出加强组织免疫力应对未来挑战的策略.
- 确定适应和恢复免疫平衡的研究领域.
主要方法:
- 对组织免疫和压力因素的当前文献进行审查和综合.
- 了解压力对免疫细胞的影响的概念框架.
- 建议潜在的治疗和研究策略.
主要成果:
- 组织免疫反应受到代谢,环境和衰老压力因素的显著影响.
- 气候变化和全球化加剧了这些挑战.
- 针对组织免疫提供了一种减轻健康风险的途径.
结论:
- 了解压力诱导的组织免疫变化至关重要.
- 制定加强组织免疫力的策略对于公众健康至关重要.
- 需要进一步研究以阐明适应和恢复机制.
相关概念视频
Cell-mediated Immune Responses
79.6K
Overview
79.6K
Special Features of Adaptive Immunity
1.7K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.7K
Transduction
545
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
545
Cells of the Adaptive Immune Response
7.3K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
7.3K
Lymphoid Cells and Tissues
2.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.2K
Immunological Memory
14.3K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.3K


