Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

5.6K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Remote ischemic conditioning for cerebral ischemia in patients with Takayasu arteritis (TARIC-1): Study protocol.

Brain circulation·2026
Same author

Panaxadiol promotes angiogenesis against chronic cerebral hypoperfusion injury through the VEGF-A/p38 MAPK/Src signaling pathway.

Journal of ginseng research·2026
Same author

Danggui-Shaoyao San Promotes Microglia-Mediated Oligodendrocyte Maturation and White Matter Repair After Stroke.

Aging and disease·2026
Same author

Soluble TREM2 Is Elevated in Pediatric Patients with Anti-NMDAR Encephalitis.

Journal of clinical medicine·2026
Same author

Live-Cell-Based Assay Outperforms Fixed Assay in MOGAD Diagnosis: A Retrospective Validation Against the 2023 International Criteria.

Diagnostics (Basel, Switzerland)·2026
Same author

The symmetrical claustrum sign in pediatric febrile infection-related epilepsy syndrome: Diagnostic value and clinical implications.

Epilepsia·2025

相关实验视频

Updated: Jul 26, 2025

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
06:54

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

2.8K

缺氧后调节促进缺血性中风后的血管生成.

Wenjie Shi1, Changhong Ren2, Wei Zhang3

  • 1North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China; Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Neuroscience
|June 18, 2023
PubMed
概括

缺氧后调节 (HPC) 促进血管生成,并改善缺血性中风后的神经功能. 这种保护作用可能涉及PLCλ和ALK5通路,增强脑损伤的恢复.

关键词:
血管新生是因为血管新生.缺氧后调节后调节缺血性中风 中风神经保护神经保护

更多相关视频

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

13.8K
Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

7.5K

相关实验视频

Last Updated: Jul 26, 2025

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
06:54

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

2.8K
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

13.8K
Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

7.5K

科学领域:

  • 神经科学是一个神经科学.
  • 心血管生物学 心血管生物学
  • 细胞生物学 细胞生物学

背景情况:

  • 缺氧后调节 (HPC) 在缺血性中风中提供神经保护,但其对中风后血管生成的影响仍然基本未知.
  • 了解HPC在血管生成中的作用对于开发用于中风恢复的新型治疗策略至关重要.

研究的目的:

  • 为了研究HPC对缺血性中风后血管生成的影响.
  • 探索潜在的机制,包括特定信号通路的参与.

主要方法:

  • 在体外:使用bEnd.3细胞评估增殖,迁移和管形成的氧气-葡萄糖剥夺 (OGD) 模型.
  • 在体内:中脑动脉封闭 (MCAO) 模型在小鼠中评估通过免疫光和西方斑点通过神经学缺陷和血管生成.

主要成果:

  • 在实验室中,HPC显著增强了内皮细胞的增殖,迁移和管形成.
  • HPC治疗改善了神经学评分,并促进了MCAO小鼠在心脏病发作周边区域的血管生成.
  • 血管新生水平与神经恢复有积极的相关性,HPC上调调节了PLCλ和ALK5表达.

结论:

  • 通过促进血管生成,HPC可以改善焦点脑缺血中的神经缺陷.
  • 在中风恢复中,HPC的亲血管效应可能通过PLCλ和ALK5信号通路进行介导.