睡眠呼吸障碍和新生儿结局之间的关联在无卵性个体中
Arlin Delgado1, Anthony M Kendle1, Tara Randis2
1Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
American journal of perinatology
|June 28, 2023
概括
怀孕中期新发的睡眠呼吸障碍 (SDB) 与新生儿并发症的增加有关. 早期怀孕SDB没有显示出与新生儿不良结果的显著关联.
科学领域:
- 产科和妇科 产科和妇科
- 新生儿健康 新生儿健康
- 睡眠医学 睡眠医学
背景情况:
- 睡眠呼吸障碍 (SDB) 是怀孕期间常见的疾病,与孕产妇的风险有关.
- 客观测量的SDB对新生儿结局的影响需要进一步调查.
研究的目的:
- 要确定在怀孕期间客观测量的睡眠呼吸障碍 (SDB) 是否会增加新生儿不良后果的风险.
- 分析SDB在怀孕早期和中期和新生儿发病率之间的关联.
主要方法:
- 对nuMom2b睡眠障碍呼吸子研究的二次分析.
- 在怀孕早期 (6-15周) 和怀孕中期 (22-31周) 进行SDB评估的家庭睡眠研究.
- 对于新生儿不良结果的复合物来计算调整后风险比率 (RR) 的日志二项式回归.
主要成果:
- 在2,106名参与者中,3%患有早期SDB,5.7%患有新发的怀孕中期SDB.
- 新生儿不良后果的发生率在早期 (29.3%) 和新发中期怀孕SDB (30.3%) 的母亲的后代中高于没有SDB (17.8%) 的母亲 (30.3%).
- 新发的怀孕中期SDB独立地与新生儿发病率的增加有关 (RR=1.43,95% CI:1.05,1.94).
结论:
- 在怀孕中期新发起的睡眠呼吸障碍与新生儿发病率的增加独立相关.
- 在调整后,早期怀孕SDB没有显示出与新生儿不良后果的统计学意义上的关联.
- 怀孕期间客观的SDB评估对于识别新生儿健康风险至关重要.
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