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[用生汁加工Magnoliae Officinalis Cortex:基于AHP-CRITIC权重方法的工艺优化和加工后的成分变化]

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  • 1School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.

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概括

使用生汁优化Magnoliae Officinalis Cortex (MOC) 的加工,可以增强像Honokiol和Magnolol这样的关键化合物. 这项研究确定了最佳的处理参数,以提高MOC质量和潜在的临床疗效.

关键词:
根据AHP-CRITIC权重方法进行权重.盒子-Behnken响应表面方法的方法.马格诺莉亚官员皮层的皮层.组成的变化,组成的变化.内容确定 内容确定过程优化优化过程优化用生汁加工而成的

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科学领域:

  • 植物化学 植物化学
  • 传统中国医学的加工加工.
  • 化学工程是化学工程的重要组成部分.

背景情况:

  • 马格诺莉亚树 (Magnoliae Officinalis Cortex,MOC) 是传统医学中一个重要的草药.
  • 加工方法对MOC的化学成分和治疗效果有很大的影响.
  • 优化MOC处理对于稳定的质量和现代制药应用至关重要.

研究的目的:

  • 为了确定生汁加工MOC (GMOC) 的最佳加工参数.
  • 调查加工机制及其对MOC化学成分的影响.
  • 为MOC建立一个稳定且可行的处理技术.

主要方法:

  • 分析层次流程 (AHP) 和标准的重要性,尽管使用标准间相关性 (CRITIC) 权重方法来赋予质量属性的重要性.
  • 采用了Box-Behnken设计,以优化加工参数,包括生汁剂量,加湿时间,温度和时间.
  • 进行了MOC,GMOC和水处理MOC (WMOC) 的比较分析,以了解加工对化学成分的影响.

主要成果:

  • 根据AHP-CRITIC方法,外观的权重系数为0.134,提取产量的权重系数为0.287,总含有Honokiol和Magnolol的权重系数为0.579.
  • 最佳的GMOC加工参数被确定为8%的生汁,120分钟的加湿时间,100°C的加工温度和7分钟的加工时间.
  • 加工降低了糖酸和酸含量,含有醇和酸含量,遵循GMOC > MOC > WMOC的趋势.

结论:

  • 对GMOC的优化加工技术是稳定的,可行的,并提高了关键活性化合物的含量.
  • 化学成分的变化,特别是红醇和磁醇,与加工的MOC的临床疗效变化相关.
  • 这项研究为现代工业生产和MOC的加工提供了宝贵的参考资料.