保留原始反射和半球连接在自闭症谱系障碍中的关系
Robert Melillo1, Gerry Leisman1,2, Calixto Machado3
1Movement and Cognition Laboratory, Department of Physical Therapy, University of Haifa, Haifa 3498838, Israel.
Brain sciences
|August 26, 2023
概括
自闭症谱系障碍 (ASD) 与大脑活动和连接能力的改变有关. 减少保留原始反射 (RPRs) 可能改善大脑网络和ASD的临床结果.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 临床神经学 临床神经学
背景情况:
- 自闭症谱系障碍 (ASD) 的特征是低频脑活动减少,高频局部活动增加.
- 保留原始反射 (RPRs) 经常在患有ASD的个体中观察到.
- 大脑网络连接模式在ASD与神经典型个体相比有所不同.
研究的目的:
- 为了研究保留原始反射 (RPRs) 和定量脑电图 (qEEG) 测量在儿童和成年人与自闭症之间的关系.
- 检查旨在减少RPR的干预措施对ASD中大脑网络连接的影响.
- 为了比较具有和没有RPR的ASD个体中的qEEG和功能连接性.
主要方法:
- 定量脑电图 (qEEG) 频谱和功能连接性分析.
- 在干预前后评估保留原始反射 (RPRs).
- 通过皮肤进行电神经刺激 (TENS) 作为一种干预措施,单方面刺激.
主要成果:
- 自闭症与异常的大脑横向化有关,包括长距离的不足连接和短距离的过度连接.
- 在ASD中观察到较高的左向右的qEEG功能连接率.
- 干预对qEEG和连接性的影响与RPRs相关分析.
结论:
- 在ASD中,临床改善和RPR的解决可能与qEEG频段的变化有关.
- 优化的大脑网络,特别是改善右半球远程连接,可能与减少RPR有关.
- 这些发现表明,通过针对RPR的干预措施,改善ASD中的大脑网络功能可能是途径.
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