循环瘤细胞和宿主免疫:一个棘手的联系
Elena Muraro1, Giulia Brisotto1
1Immunopathology and Cancer Biomarkers Units, Department of Translational Research, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy.
International review of cell and molecular biology
|September 22, 2023
概括
在转移期间,循环瘤细胞 (CTC) 与免疫系统相互作用. 了解这种复杂的交互可能会通过综合监测来改善癌症患者的管理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症转移 癌症转移
背景情况:
- 循环瘤细胞 (CTC) 对转移至关重要.
- 免疫系统在转移级联中发挥着复杂的作用,影响CTCs.
- 免疫细胞可以表现出抗瘤和促进瘤的活动.
研究的目的:
- 描述参与CTC-免疫系统对话的免疫细胞.
- 从CTC和免疫细胞的角度详细介绍相互作用的机制.
- 审查监测CTC和免疫细胞的预后作用.
主要方法:
- 关于免疫细胞与CTC相互作用的文献综述.
- 对CTC-免疫细胞交叉交叉机制的分析.
- 综合证据的预后价值.
主要成果:
- 确定了关键的免疫细胞 (NK细胞,T淋巴细胞,中性粒细胞,巨细胞等). 参与CTC传播工作.
- 描述了CTC与免疫细胞相互作用的直接和间接机制.
- 强调了免疫细胞的双重作用:抗瘤和免疫抑制.
结论:
- CTC和免疫细胞之间的相互作用是一个复杂的,双向的过程.
- 监测CTC和免疫细胞对于癌症管理具有预后潜力.
- 对这种对话的进一步研究可以为治疗策略提供信息.
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