一个进化机器学习多发性骨髓瘤使用Runge Kutta优化器从多特征索引的进化机器学习
Yazhou Ji1, Beibei Shi2, Yuanyuan Li1
1Department of Hematology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.
Computers in biology and medicine
|October 20, 2023
概括
这项研究介绍了MSRUN-KELM,这是一种新的机器学习框架,用于使用多特征索引诊断多发性骨髓瘤 (MM). MSRUN-KELM实现了高精度,为MM诊断提供了潜在的新工具.
科学领域:
- 计算生物学是一种计算生物学.
- 医疗信息学医学信息学
- 机器学习 机器学习
背景情况:
- 多发性骨髓瘤 (MM) 是一种严重的血液性恶性瘤,占美国所有癌症的1.8%.
- 准确和早期诊断MM对于有效的患者管理至关重要.
研究的目的:
- 开发和评估用于使用多特征索引诊断多发性骨髓瘤 (MM) 的机器学习框架.
- 通过优化的粘液模具Runge Kutta Optimizer (MSRUN) 来提高内核极端学习机器 (KELM) 的性能.
主要方法:
- 在Runge Kutta Optimizer (RKO) 中集成了一个新的粘液模具学习操作员,以创建MSRUN,提高搜索性能.
- 在MM诊断的MSRUN-KELM框架内,MSRUN被用于同步的参数优化和特征选择.
- 使用IEEE CEC2014基准函数验证了MSRUN算法.
主要成果:
- 与标准RKO相比,MSRUN算法显示了显著改善的搜索性能.
- 在MSRUN-KELM框架下,多发性骨髓瘤的诊断准确率达到93.88%.
- 关键性能指标包括0.922677的马修斯相关系数和93.41%和93.19%的灵敏度.
结论:
- MSRUN-KELM框架是分析多个特征指数用于多发性骨髓瘤诊断的有效工具.
- 这种方法显示出作为多发性骨髓瘤的潜在诊断工具的希望.
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