对侵略性的直接和间接遗传影响
Camiel M van der Laan1,2, Steve G A van de Weijer2, René Pool1
1Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Biological psychiatry global open science
|October 26, 2023
概括
遗传因素会影响侵略性,但间接的遗传影响并不显著. 早期侵略性,ADHD和教育的多基因分数显示了直接的,尽管很小,对攻击性行为的影响.
科学领域:
- 行为遗传学 行为遗传学
- 精神病学是一个精神病学.
- 人类行为人类行为.
背景情况:
- 侵略性显示出家族相似性,遗传学解释了约50%的变异.
- 基因型与环境的相关性可能部分解释了对侵略的遗传影响.
- 调查间接的多基因分数 (PGS) 影响对于理解遗传贡献至关重要.
研究的目的:
- 检查间接多基因评分 (PGS) 对侵略的影响.
- 区分直接和间接的遗传影响对攻击性行为.
主要方法:
- 模拟PGS效应,使用全基因组关联研究来研究生命早期的侵略性,教育成就和ADHD.
- 使用了家族内部和家族间的设计,并采用了来自荷兰双胞胎登记册的大量数据.
- 采用传染/非传染PGS设计来评估遗传影响.
主要成果:
- 在任何设计中都没有发现PGS对侵略的间接影响的证据.
- 在早期的侵略性,ADHD和教育成就方面观察到PGS对侵略性的显著直接影响.
- 直接影响的解释变异很低,范围在0.2%至0.9%之间.
结论:
- 直接的遗传影响,而不是间接的影响,影响侵略性,与之前的双胞胎和家庭研究保持一致.
- 需要对多种PGS进行进一步的研究,以概括对侵略性遗传影响的发现.
相关概念视频
Aggression
27.8K
Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
27.8K
Behavioral Genetics and Its Designs
381
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
381
Human Genetics
588
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
588
Inheritance
398
Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype...
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype...
398
Secondary Motives: Affiliation Motivation and Aggression Motivation
343
Affiliation motivation is the intrinsic desire to connect with others and belong to a social group, which plays a crucial role in forming and maintaining personal relationships. This type of motivation is essential for psychological well-being, as it provides individuals with a sense of community and support. An example of this is a student who joins a study group in order to feel a sense of connection. People with high affiliation motivation actively seek social approval, take satisfaction in...
343
Gene-Environment Interactions
332
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
332


