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The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
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Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
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前列腺癌,种族和健康差异:我们所知道的

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前列腺癌 (PCa) 结果显示非洲裔美国男性的差异,受遗传因素和系统不平等的影响. 解决健康的社会决定因素和确保公平的护理对于改善前列腺癌存活率至关重要.

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科学领域:

  • 在瘤学瘤学.
  • 健康差距 研究 研究 研究 研究
  • 遗传学 遗传学 是一个

背景情况:

  • 前列腺癌 (PCa) 不成比例地影响非裔美国男性,通常在晚期呈现.
  • 在PCa结果中的差异引发了关于先天生物学,遗传学和社会经济因素的相互作用的问题.
  • 种族是一种社会构造,但种族主义明显影响健康结果和生物过程.

研究的目的:

  • 探索导致非洲裔美国男性前列腺癌差异的复杂因素.
  • 区分遗传倾向与社会决定因素和医疗保健准入在PCa结果中的作用.
  • 检查种族和种族主义对前列腺癌生物学和临床表现的影响.

主要方法:

  • 对鉴定西非血统人口中PCa风险等位基因的遗传研究的审查.
  • 在瘤免疫学中对人口水平差异的分析.
  • 检查结构性种族主义和医疗保健获取对PCa临床结果的影响.

主要成果:

  • 西非血统的人群显示前列腺癌风险等位基因的丰富.
  • 在人群层面上存在瘤免疫学的差异.
  • 有证据表明,可比的医疗保健质量会导致可比的PCa结果,不论种族.

结论:

  • 遗传倾向和社会/健康不公正都导致前列腺癌差异.
  • 结构性种族主义在PCa临床结果中观察到的差异中发挥着重要作用.
  • 公平获得高质量的医疗保健对于缓解前列腺癌结果差异至关重要.