Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Computed Tomography01:10

Computed Tomography

4.5K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Kinetic Modeling of a Novel Putative Sphingosine-1-Phosphate Receptor 1 (S1PR1) Radiotracer [<sup>18</sup>F]TZ82112 in Nonhuman Primates.

Journal of neurochemistry·2026
Same author

Design, synthesis, and characterization of F-18 sigma-1 receptor radiotracers for Alzheimer disease.

European journal of medicinal chemistry·2026
Same author

The association of late-life depressive symptoms with brain amyloid-β deposition: the ARIC-PET study.

Aging brain·2025
Same author

Multimodality Imaging in Evaluation of the Acute Scrotum.

Radiographics : a review publication of the Radiological Society of North America, Inc·2025
Same author

Estimating preclinical amyloid positivity: A case study transporting ADNI to ARIC.

Alzheimer's & dementia (New York, N. Y.)·2025
Same author

Birth weight, incident dementia risk, and PET amyloid burden: The ARIC study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

相关实验视频

Updated: Jul 8, 2025

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
07:33

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Published on: November 8, 2024

445

改进了使用CT衍生的缩放因子进行MicroPET/CT成像的量化.

Ayon Nandi1, Masayoshi Nakano2, James Robert Brašić3

  • 1Johns Hopkins School of Medicine: The Johns Hopkins University School of Medicine.

Research square
|December 11, 2023
PubMed
概括

基于CT的联合注册 (PTCT) 在动物微PET/CT研究中提高了大脑尺寸的准确性. 与传统的基于PET的联合注册相比,这种方法提高了不可移动的结合潜力 (BPND) 估计.

更多相关视频

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

629
Contrast Enhanced Vessel Imaging using MicroCT
05:50

Contrast Enhanced Vessel Imaging using MicroCT

Published on: January 27, 2011

12.6K

相关实验视频

Last Updated: Jul 8, 2025

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
07:33

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Published on: November 8, 2024

445
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

629
Contrast Enhanced Vessel Imaging using MicroCT
05:50

Contrast Enhanced Vessel Imaging using MicroCT

Published on: January 27, 2011

12.6K

科学领域:

  • 神经科学是一个神经科学.
  • 医疗成像医学成像
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 组合的微PET/CT扫描仪对于研究动物大脑疾病至关重要.
  • 准确的共同注册对于可靠的PET数据分析至关重要,特别是用于估计约束潜力.

研究的目的:

  • 评估基于CT的联合注册是否可以在动物PET研究中增强大脑尺寸估计.
  • 为了确定改进的维度估计是否转化为更准确的非可移位结合电位 (BPND) 测量.

主要方法:

  • 使用mGluR5放射追踪器[18F]FPEB从CD-1小鼠获得的PET和CT扫描.
  • 开发了一种PET/CT (PTCT) 联合注册方法,使用CT衍生缩放因子定制标准卷.
  • 对比PTCT与传统的基于PET的联合注册 (PT9,PT12) 在14个大脑区域的BPND估计.

主要成果:

  • 基于PET的方法低估了缩放因子,导致小脑放射性的高估高达20%.
  • 传统的PET联合注册导致目标地区的BPND严重低估 (高达-50%).
  • 与基于PET的方法相比,PTCT显示了个体动物头骨与标准头骨的更好一致.

结论:

  • 传统的基于PET的联合注册可以在BPND估计中引入偏差,特别是在使用小脑作为参考区域时.
  • 拟议的基于CT的联合注册 (PTCT) 为使用微PET/CT的动物大脑研究提供了定量改进.