岛皮层的内在功能聚类
Lotte Sypré1,2, Saloni Sharma3, Dante Mantini2,4
1Laboratory for Neuro- & Psychophysiology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Frontiers in integrative neuroscience
|January 22, 2024
概括
层次分类揭示了岛的四个集群组织,表明对感官和社会处理的功能专业化. 将聚类与其他方法结合起来,可以更详细地了解岛屿的功能.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 灵长类大脑研究研究
背景情况:
- 灵长类昆虫的功能组织是复杂的,通过架构,连接和功能来研究.
- 基于连接的分片方法在人类岛屿研究中很受欢迎,但它们的功能有效性仍在争论中.
研究的目的:
- 通过使用等级分类来研究岛的功能组织.
- 为了确定数据驱动的集群方法是否产生了岛屿的有意义的功能细分.
主要方法:
- 在岛数据上使用分层分类,探索2-10个集群解决方案.
- 使用指纹,轮和肘部方法进行集群验证.
- 分析了已识别的集群的功能响应特性和大脑范围连接性.
主要成果:
- 通过多种验证方法,确定了四个集群解决方案是最佳的.
- 这四个集群显示了对口味,体力运动,前庭和社会视觉处理的功能专业化.
- 在较高的集群数量出现了更详细的功能差异化,突出了纯数据驱动方法的局限性.
结论:
- 基于静止状态的层次聚类提供了一个有意义的,尽管部分详细的,关于insula功能组织的描述.
- 将基于连接的分片与其他神经成像模式相结合,对于全面了解insula子场功能至关重要.
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