评估心内压力使用和声辅助压力估计和声纳体微气泡进行心内压力评估
Cara Esposito1, Priscilla Machado1, Maureen E McDonald1
1From the Departments of Radiology (C.E., P.M., F.F., J.K.D.), Medical Imaging and Radiation Sciences (M.E.M.), and Medicine (M.P.S., D.F., P.M., I.S.C., N.R., P.W., A.V., M.D.), Thomas Jefferson University, Philadelphia, Pa; Clarius Mobile Health, Vancouver, Canada (K.D.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.K.D).
Radiology. Cardiothoracic imaging
|February 15, 2024
概括
亚波辅助压力估计 (SHAPE) 技术显示出使用Sonazoid微气泡进行非侵入性测量右心室静脉压和左心室静脉压的前景,这可能会减少侵入性心脏导管治疗的需要.
科学领域:
- 心血管成像和诊断系统
- 超声波对比剂 超声波对比剂
- 血液动力学监测 血液动力学监测
背景情况:
- 精确测量右心室 (RV) 缩压和左心室 (LV) 腹缩压对于诊断和管理心血管疾病至关重要.
- 目前的方法通常依赖于侵入性心脏导管,这带有固有的风险和局限性.
- 寻求非侵入性技术,以提供更安全,更容易获得的血液动力学评估.
研究的目的:
- 评估用于非侵入性确定RV缩压和LV透缩压的亚波辅助压力估计 (SHAPE) 技术的可行性.
- 与标准心脏导管方法相比,使用Sonazoid微气泡评估SHAPE的准确性.
主要方法:
- 一项前性临床试验招募了接受左心和/或右心导管治疗的患者.
- 索纳微气泡被静脉注射,SHAPE数据与侵入性压力测量 (液体填充和固态导管) 同步获得.
- 从袖口压力和大动脉亚波信号中获得的转换因子被用于将SHAPE信号转换为压力值.
主要成果:
- 与充满液体的导管相比,SHAPE技术显示RV缩压的平均误差为1.6mmHg ± 1.5mmHg ± 6.2mmHg,LV最小透缩压的平均误差为8.4mmHg ± 6.2mmHg.
- 静脉末透压的误差为7.4mmHg ± 5.7 (相对于液体充满的) 和6.8mmHg ± 3.3 (相对于固态).
- SHAPE技术显示出临床相关压力测量的潜力,P值表明大多数比较的统计学意义或近乎意义.
结论:
- 当与Sonazoid微气泡一起使用SHAPE技术时,它显示了对RV缩压和LV透缩压的非侵入性估计的潜力.
- 这种非侵入性方法可以为血液动力学评估提供一种有价值的替代方法,而不是侵入性心脏导管.
- 需要进一步验证和临床实施,以确定其在心血管诊断中的作用.
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