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相关概念视频

Chair Conformation of Cyclohexane02:02

Chair Conformation of Cyclohexane

14.6K
The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
14.6K
Conformations of Cyclohexane02:11

Conformations of Cyclohexane

12.5K
Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
12.5K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

8.8K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
8.8K
Stability of Substituted Cyclohexanes02:30

Stability of Substituted Cyclohexanes

12.6K
This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
12.6K
Conserved Binding Sites01:49

Conserved Binding Sites

4.2K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
4.2K
Stability of Conjugated Dienes01:28

Stability of Conjugated Dienes

3.4K
Introduction
A comparison of the enthalpies of hydrogenation of dienes reveals that conjugated dienes release less heat on hydrogenation, rendering them more stable than their nonconjugated analogs.
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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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对ConA结合和结构稳定性中的循环顺序作用的计算洞察力.

Vinicius J S Osterne1, Vanir R Pinto-Junior2,3, Messias V Oliveira2

  • 1Laboratory of Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000, Ghent, Belgium.

Current research in structural biology
|April 1, 2024
PubMed
概括

康卡纳瓦林A (ConA) 的加工显著提高了莱克的稳定性,特别是保持了它的四重体形式. 这种到期不会实质性地改变ConaA.

关键词:
生物信息学是一种生物信息学.循环变换是一个循环变换.康卡纳瓦林 (Concanavalin) 是一个莱克是一种学菌素.

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科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 结构生物学 结构生物学

背景情况:

  • 康卡纳瓦林A (ConA) 是一种经过充分研究的,具有多样化应用的莱克.
  • ConA的翻译后处理和循环排列的确切目的尚不清楚.
  • 了解这些修改对于阐明Cona的功能机制至关重要.

研究的目的:

  • 研究翻译后修改对ConA稳定性和碳水化合物结合性质的影响.
  • 为了比较未经加工的ProConA和成熟的ConA的结构和动态特性.
  • 为了阐明 ConA 处理的功能意义.

主要方法:

  • 利用 200 ns 的分子动力学模拟对 ProConA 和 ConA 的单体和小分子形式进行了模拟.
  • 分析了与D-曼诺斯和GlcNAc2Man9 N-glycan结合的未结合的讲蛋白和复合物的轨迹数据.
  • 进行了稳定性参数,相互作用概况和结合自由能量的比较分析.

主要成果:

  • 与ConA相比,ProConA的稳定性参数在单体和四体水平上显著较低.
  • 无论是ProConA还是ConA,都表现出类似的碳水化合物结合特性,包括相互作用概况和结合自由能量.
  • 处理ProConA增强了成熟的ConA的稳定性,特别是在维持四重体寡合物方面.

结论:

  • 康纳处理在增强莱克稳定性,特别是四聚体形成方面发挥着至关重要的作用.
  • 成熟并没有显著改变ConA.的基本碳水化合物结合能力.
  • 这项研究提供了对莱克结构和功能的翻译后修饰的功能重要性的见解.