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相关概念视频

RNA Structure01:19

RNA Structure

4.8K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
4.8K
RNA Stability01:53

RNA Stability

33.5K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.5K
Nucleic Acid Structure01:25

Nucleic Acid Structure

6.1K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.1K
Nucleic Acids02:43

Nucleic Acids

44.1K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
44.1K
Nucleic acids02:43

Nucleic acids

161.8K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
161.8K
Protein Organization01:13

Protein Organization

137.3K
Overview
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相关实验视频

Updated: Jun 25, 2025

Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

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RNA二次结构 热力学 热力学

Ronny Lorenz1

  • 1Department of Theoretical Chemistry, University of Vienna, Vienna, Austria. ronny@tbi.univie.ac.at.

Methods in molecular biology (Clifton, N.J.)
|May 23, 2024
PubMed
概括
此摘要是机器生成的。

基于物理学的方法提供了一个严格的方法,通过模拟带有自由能量的循环来预测RNA二次结构. 这允许对RNA结构空间进行详细分析,并更容易地将实验数据集成到功能研究中.

关键词:
平衡的概率可能存在.最低的自由能源结构.结合RNA与蛋白质的RNA-蛋白质结合结构约束 结构约束低于最佳的结构.

更多相关视频

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

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Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

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相关实验视频

Last Updated: Jun 25, 2025

Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

14.8K
RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

31.5K
Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

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科学领域:

  • 计算生物学 计算生物学
  • 生物物理学的生物物理.
  • 分子生物学分子生物学

背景情况:

  • 预测RNA二级结构对于理解RNA功能至关重要.
  • 现有的方法包括统计 (如SCFGs) 和机器学习方法,在已知的结构上进行训练.
  • 基于物理学的方法提供了一个替代方案,即利用RNA循环的实验或数学衍生的自由能量.

研究的目的:

  • 突出基于物理的方法对RNA二次结构预测的优点.
  • 为了证明他们的能力在探索RNA的 conformational 景观.
  • 展示它们在整合实验数据方面的潜力,例如联结.

主要方法:

  • 模拟RNA二次结构,使用循环作为具有分配自由能量的构建块.
  • 应用统计力学来确定RNA结构的平衡概率.
  • 利用高效的算法来分析构造状态空间.

主要成果:

  • 基于物理学的模型为RNA二次结构预测提供了一个严格的框架.
  • 它们可以对RNA构造组合及其特性进行全面分析.
  • 这些模型有助于整合实验数据,如RNA-带相互作用.

结论:

  • 基于物理学的方法为RNA二次结构预测提供了一种强大而可扩展的方法.
  • 它们提供了对RNA结构动态和功能的更深入的见解.
  • 它们结合实验数据的能力提高了它们在研究RNA - 连接体相互作用及其功能影响方面的实用性.