eRF12

Alexey Shuvalov1,2, Alexandr Klishin1, Nikita Biziaev1

  • 1Engelhardt Institute of Molecular Biology, The Russian Academy of Sciences, 119991 Moscow, Russia.

概括

一个新发现的人类eRF1异型2在调节翻译终结方面发挥了作用. 这种尚未研究的异型与核糖体子单元相互作用,但显示活性降低,影响停止子读透和翻译效率.

相关概念视频

Regulation of the Unfolded Protein Response01:31

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Master Transcription Regulators02:23

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Enzyme-linked Receptors01:00

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Endoplasmic Reticulum01:39

Endoplasmic Reticulum

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