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Updated: Jun 18, 2025

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
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Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

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O-GlcNAcα-Synuclein的修饰可以改变单体动力学以控制聚合动力学

Kasun Gamage1, Binyou Wang2, Eldon R Hard2

  • 1Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48824, United States.

ACS chemical neuroscience
|July 31, 2024
PubMed
概括

翻译后的修改,如O-GlcNAcylation,对α-Synuclein聚合有不同的影响. 在T72的糖化减缓了聚合,而S87可能会加速早期阶段,表明修改不会在神经退行性疾病中均地影响蛋白质凝聚.

关键词:
帕金森病是帕金森氏症的一种疾病.聚合方式 聚合方式 聚合方式葡萄糖酶化是什么? 葡萄糖酶化是什么?分子内扩散是分子内扩散.后翻译修改后的修改.α-Synuclein 是一种蛋白质.

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