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灵活控制前皮层中的序列工作记忆
Jingwen Chen1, Cong Zhang1, Peiyao Hu1
1Institute of Neuroscience, Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
Neuron
|August 23, 2024
概括
大脑通过在前皮层组织神经活动来灵活地控制序列工作记忆 (SWM). 这样可以将项目绑定到正确的召回顺序.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 记住序列需要将项目绑定到它们的排名顺序.
- 控制序列工作记忆 (SWM) 的神经机制尚未得到充分理解.
研究的目的:
- 调查SWM的基础的神经表征和控制机制.
- 探索大脑如何在SWM中结合物品和排序信息.
主要方法:
- 电生理学记录在子的额叶皮层.
- 执行前后顺序工作记忆任务.
- 在低维子空间内分析神经群体动态.
主要成果:
- 在前额叶皮层中确定了用于感觉和记忆信息的单独的,可概括的子空间.
- 在这些子空间内观察到的有组织的动态反映了SWM控制.
- 根据任务需求,证明了感觉信息的灵活路由到基于等级选择的SWM子空间.
- 在SWM子空间中的神经活动预测了被召回的项目和顺序,即使在错误试验中.
结论:
- 额叶皮层中编排动态的组成神经群体代码支持灵活的SWM控制.
- 这些发现揭示了大脑如何在工作记忆中管理有序信息的神经框架.
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