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丧的没有奖励:行为,电路,神经化学和疾病
Mauricio R Papini1, Thomas A Green2, Yorkiris Mármol Contreras2
1Department of Psychology, Texas Christian University, Fort Worth Texas 76129 m.papini@tcu.edu.
概括
丧的非奖励 (FNR),由于缺乏资源而引起的厌恶情绪,影响行为和生理学. 最近的研究,受到NIMH RDoC倡议的推动,探索了FNR.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 行为科学 行为科学
背景情况:
- 丧性不奖励 (FNR) 是一种因遗漏或减少重要资源而引发的厌恶情绪.
- FNR显著影响动机,焦虑,学习,社交行为和攻击性.
- 关于FNR的研究经历了下降,但被NIMH研究领域标准 (RDoC) 倡议振兴.
研究的目的:
- 审查与精神疾病相关的动物模型和与FNR相关的症状.
- 介绍最近在识别参与FNR的大脑区域和神经递质方面的进展.
- 将FNR研究与现实世界的现象联系起来,例如COVID-19流行病的心理影响.
主要方法:
- 对现有的关于令人丧的不奖励的文献进行了审查.
- 对表现出与FNR相关的行为和生理学的动物模型的分析.
- 识别神经生物学基质 (大脑区域和神经递质),涉及到FNR.
主要成果:
- FNR是包括物质使用障碍,抑郁症,焦虑症和侵略性在内的疾病的关键调解者.
- COVID-19大流行突显了FNR的社会影响,将限制与增加的物质使用和社会冲突相关联.
- 在精确定位特定大脑区域和参与FNR的神经递质系统方面取得了进展.
结论:
- FNR是理解负价值精神疾病的关键构造.
- 动物模型为FNR的神经生物学及其临床相关性提供了宝贵的见解.
- 对FNR机制的持续研究对于开发有效的治疗策略至关重要.
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