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Updated: Jun 10, 2025

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
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Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

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应用机器学习和SERS用于DNA二次结构的精确类型化.

Guantong Xu1, Ying Bao2, Yujing Zhang1

  • 1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China.

Analytical chemistry
|October 16, 2024
PubMed
概括

这项研究将机器学习与表面增强拉曼光谱学 (SERS) 结合起来,以准确识别像G-quadruplex (G4) 和i-motif (iM) 这样的DNA二次结构. 这种新方法可以快速选和预测各种DNA结构.

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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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