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用于固体癌症患者的 GPC3 CAR T 细胞

David Steffin1,2,3,4, Nisha Ghatwai1,2, Antonino Montalbano1,2

  • 1Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Nature
|November 28, 2024
PubMed
概括

干白素-15 (IL-15) 增强化学抗原受体 (CAR) 的T细胞治疗固体瘤. 与GPC3 CAR T细胞同时表达IL-15可以改善患者的反应和瘤透.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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