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相关概念视频

Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

375
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
375
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

309
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
309
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

3.2K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
3.2K
Drug Delivery: Overview01:16

Drug Delivery: Overview

276
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
276
Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

2.7K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
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Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

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Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
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相关实验视频

Updated: Jun 3, 2025

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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基于eutectogel的药物输送:阿提诺洛尔的创新方法

Roberta Cassano1, Roberta Sole1, Carlo Siciliano1

  • 1Dipartimento di Farmacia, Salute e Scienze della Nutrizione, Università della Calabria, Arcavacata di Rende, 87036 Cosenza, Italy.

Pharmaceutics
|January 8, 2025
PubMed
概括

新型尤特克托格尔增强了阿提诺洛尔的通过皮肤输送. 这些系统使用深度浸泡溶剂 (DES),与传统水凝相比,药物释放量显著增加,为心血管药物输送提供了有希望的替代方案.

关键词:
抗高血压药物的使用.这就是Atenolol.深层欧性溶剂 深层欧性溶剂药物输送是药物输送的过程.欧特克托格尔 (eutectogel) 是一种在体内形成的物质.绿色的溶剂 绿色的溶剂这是β-阻断剂.

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Last Updated: Jun 3, 2025

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10:28

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科学领域:

  • 制药科学 制药科学
  • 药物输送系统 药物输送系统
  • 材料科学 材料科学 材料科学

背景情况:

  • 高血压影响全球32%的成年人,导致大量的心血管药物使用.
  • 阿提诺洛尔 (Atenolol) 是一种BCSIII类药物 (可溶性高,透性低),广泛用于心血管疾病.
  • 通过皮肤传递的系统正在获得兴趣,以改善患者的遵守性和成本效益.

研究的目的:

  • 开发和评估新的eutectogels,以增强通过皮肤递送阿提诺洛尔.
  • 为了研究深度浸泡溶剂 (DESs) 在提高阿提诺洛的局部生物可用性方面的潜力.

主要方法:

  • 制备了一种由胆化物 (HBA) 和乙醇 (HBD) 组成的深度浸泡溶剂 (DES).
  • 通过光谱和热力学研究证实了DES中阿诺洛的溶解性,这表明了键的形成.
  • 使用凝和Tego Carbomer 140制备了eutectogels,随后进行了表征 (风病学,胀,透研究).

主要成果:

  • 与传统水凝相比,eutectogels表现出更高的性能.
  • 基于碳烯的eutectogels实现了86%的阿提诺洛释放率,而基于凝的eutectogels达到51%.
  • 传统的水凝释放率明显较低 (分别为27%和35%).

结论:

  • 开发的eutectogels显示出有效的通过皮肤递送atenolol的显著潜力.
  • 这项研究强调了eutectogels作为一个有希望的平台,以克服通过皮肤递送药物的透性挑战.