临床和操作决策的数字双胞胎:范围审查
Vahid Riahi1, Ibrahima Diouf1, Sankalp Khanna2
1Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Melbourne, Australia.
Journal of medical Internet research
|January 8, 2025
概括
医疗保健中的数字双胞胎 (DTs) 显示出改善临床和操作决策的前景. 虽然许多应用程序专注于决策,但当前的系统尚未充分利用DT功能.
科学领域:
- 数字健康数字健康
- 医疗信息学 医疗信息学
- 应用的人工智能应用的人工智能
背景情况:
- 医疗保健行业越来越多地采用数字技术来应对不断变化的挑战.
- 数字双胞胎 (DTs),即与实体对应物实时交互的虚拟表征,因其在医疗保健中的变革潜力而受到关注.
- 尽管有个性化护理和治疗优化等多种应用,但对DTs在卫生系统中的定义和实施缺乏清晰的理解.
研究的目的:
- 审查数字双胞胎 (DTs) 在医疗保健中的应用,特别是临床决策 (CDM) 和操作决策 (ODM).
- 通过检查其核心元素和特征,建立DT的定义和框架.
- 根据定义的DT特征,评估支持CDM和ODM的DT应用程序的当前进展和范围.
主要方法:
- 根据PRISMA-ScR协议进行了范围审查.
- 在多个数据库 (PubMed,MEDLINE,Scopus) 进行了搜索,以寻找医疗系统CDM和ODM中DDT的原始研究.
- 仅提出想法或框架,或缺乏实验数据的研究被排除在外. 用描述性统计数据收集和分析了关于DT特征,测试环境和方法的数据.
主要成果:
- 在5537篇论文中,86篇 (1.55%) 符合纳入标准,所有论文都于2017年后发表.
- 大多数研究重点是临床决策 (CDM) (75/86). 数学建模和模拟是最常见的方法.
- 主要应用领域包括循环系统疾病,健康状况以及内分泌/营养/代谢疾病. 只有19%的研究在真实环境中进行了测试;大多数使用模拟. 开发的系统还没有充分发挥DT的全部潜力.
结论:
- 本综述提供了医疗保健中用于临床和操作决策 (CDM/ODM) 的数字双胞胎 (DT) 应用的全面概述.
- 介绍了一个新的框架,定义了医疗保健中的DT元素和特征.
- DT应用显示出未来在疾病诊断,预防,临床试验设计和个性化,优化治疗中的角色的前景.
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