鼠标驱动器和调节器皮质-甲状腺-皮质电路的互补组织
Rachel M Cassidy1,2, Angel V Macias1, Willian N Lagos1
1The Salk Institute for Biological Studies, La Jolla, California 92037.
概括
鼠标视觉系统中的皮层-甲状腺-皮层 (CTC) 电路显示了第五层和第六层输入到脉动器的不同规则,影响了感官处理和皮层相互作用.
科学领域:
- 神经科学是一个神经科学.
- 视觉系统研究 视觉系统研究
- 电路映射 电路映射 电路映射
背景情况:
- 皮质皮质 (CC) 投影使层次视觉处理成为可能.
- 间接的皮质 - thalamo - 皮质 (CTC) 途径通过脉动继电器传递感官信号,并调解皮质相互作用.
- 在老鼠视觉系统中, transthalamic 路径的组织在很大程度上仍然没有特征.
研究的目的:
- 阐明鼠标视觉系统中CTC电路的组织原理.
- 为了确定 transthalamic 路径是否连接所有较高的视觉区域 (HVA),并遵循系统的规则.
- 为了映射到不同HVA投射到脉动神经元的输入/输出关系.
主要方法:
- 内在信号成像被用来绘制小鼠中的HVA.
- 投影特定的狂犬病追踪针对五个pulvinar→HVA通路.
- 死后皮质组织与体内地图对齐,以精确量化投射区域和细胞类型.
主要成果:
- 第5层皮质体 (L5CT) "驱动器"输入主要来自主要视觉皮层 (V1).
- 来自侧面HVA的L5CT输入避免驱动互联连接,支持"没有强循环"假设.
- 第六层皮质体层 (L6CT) "调节器"输入广泛分布,有利于相互连接.
- 所有的HVA都从上层结合体接收异突触输入.
结论:
- 脉冲器中的CTC电路根据目标HVA和输入电池类型进行组织.
- 驾驶和调节更高阶路径遵循互补的连接规则,反映了第一阶皮质 - thalamic 电路.
- 这些发现揭示了老鼠视觉系统中 transthalamic 途径的系统组织.
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