冠状病毒疫苗与月经变化有关:移动应用程序研究
Sung Eun Kim1, Joseph J Noh2, Yoo-Young Lee2
1Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Obstetrics & gynecology science
|February 9, 2025
概括
接种COVID-19疫苗与月经间出血 (IMB) 发生率和持续时间的增加有关. 虽然在统计学上显著,但在接种疫苗后,这些月经模式的变化在临床上没有意义.
科学领域:
- 生殖健康 生殖健康
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 自2019年新冠肺炎 (COVID-19) 疫苗接种开始以来,经常报告异常子宫出血 (AUB).
- 了解COVID-19疫苗接种和月经不规则之间的关系对于公共卫生至关重要.
- 以前的研究表明,疫苗接种和月经周期变化之间存在潜在联系.
研究的目的:
- 评估COVID-19疫苗接种与异常子宫出血 (AUB) 之间的关联.
- 调查疫苗接种后发生的月经间出血 (IMB) 发生率,持续时间和数量的变化.
- 分析COVID-19疫苗接种对月经持续时间,周期长度和相关症状的影响.
主要方法:
- 使用月经周期的移动应用程序数据进行回顾性队列研究.
- 在接种COVID-19疫苗之前和之后,对月经间出血 (IMB) 发生率,持续时间和数量的分析.
- 检查月经持续时间,周期长度,以及与疫苗接种状态和疫苗类型相关的症状变化.
主要成果:
- 在接种疫苗后,月经间出血 (IMB) 的患病率增加到3.35% (OR, 1.61).
- IMB的持续时间增加了0.43天,更重的IMB的比例增加了 (OR,2.96).
- 月经周期长度增加了1.39天 (p<0.0001),IMB患病率无论疫苗类型如何都在增加.
结论:
- 接种COVID-19疫苗对IMB患病率,持续时间,数量和月经周期长度产生了统计学上显著的影响.
- 这些观察到的月经变化虽然在统计学上是显著的,但在临床上没有被认为是有意义的.
- 接种疫苗后的月经变化通常在正常范围内.
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