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Updated: Apr 12, 2026

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通过基于RNA的纳米颗粒传染:比较封装与吸附方法对RNA的整合

Amy E Laturski1, Maria T Dulay2, Jillian L Perry3

  • 1Department of Chemistry, Stanford University, Stanford, California 94305, United States.

Bioconjugate chemistry
|February 25, 2025
PubMed
概括

传统上使用纳米颗粒进行RNA输送的方法是封装. 最近的进展表明吸附是一种可行的替代方案,为RNA纳入纳米粒子提供了新的策略.

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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