超加工食品和神经精神病学结果:假定机制
Mariane Lutz1,2, Marcelo Arancibia1,2, Javier Moran-Kneer1,3
1Center for Translational Studies in Stress and Mental Health (C-ESTRES), Universidad de Valparaíso, Valparaíso 2360102, Chile.
Nutrients
|April 12, 2025
概括
超加工食品 (UPF) 与健康状况不佳,特别是神经精神疾病有关. 这篇评论探讨了UPFs如何使用UPF.
科学领域:
- 营养神经科学 营养神经科学
- 公共卫生 营养 公共卫生 营养
- 饮食精神病学 饮食精神病学
背景情况:
- 越来越多的证据将超加工食品 (UPF) 与不良健康结果联系起来.
- 临床前和观察性研究表明,UPF会增加神经精神疾病的风险.
研究的目的:
- 审查高UPF摄入量对神经心理健康产生负面影响的机制.
- 突出UPFs在神经炎症,氧化应激和表观遗传变化的作用.
主要方法:
- 现有科学文献的叙述性审查.
- 临床前,观察和饮食干预研究的分析.
- 讨论拟议的生物和化学途径.
主要成果:
- 通过高热量密度,糖,,添加剂和低纤维,UPFs导致神经精神病的不良结果.
- 热处理产生有害化合物 (例如,糖毒素),影响肠-大脑轴.
- UPFs影响肠道微生物群,导致神经炎症,氧化应激和神经退行.
- UPFs的表观遗传效应可能解释了精神健康障碍的代际遗传.
结论:
- 高UPF消费与神经退行,认知衰退,痴呆和情绪障碍有关.
- 促进健康的饮食模式在所有生命阶段至关重要,以减轻与UPF相关的风险.
- 解决健康的商业决定因素是必要的,以改善饮食模式和心理健康.
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