复杂水样中的药用活性化合物的分析:作为一种选择的样本过
Sofia Silva1, João Rodrigues2, Vitor V Cardoso1
1Direção de Laboratórios, Empresa Portuguesa das Águas Livres, S.A.-EPAL, 1800-031 Lisboa, Portugal.
Molecules (Basel, Switzerland)
|April 26, 2025
概括
在分析药用活性化合物 (PhAC) 之前过废水不会显著改变结果. 这项研究发现过和未过样本之间的PhAC量化没有显著差异,优化了复杂水矩阵的样本准备.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
背景情况:
- 样品预处理对于染色体分析的成功至关重要,特别是在废水等复杂矩阵中.
- 药用活性化合物 (PhAC) 分析通常涉及固相提取 (SPE) 和UPLC-MS/MS.
- 废水中的高有机物质需要过,以防止SPE弹堵塞并提高效率.
研究的目的:
- 确定在废水和地表水中量化PhAC的最佳预处理方法.
- 评估SPE之前过水样是否会影响PhAC恢复.
- 调查PhAC度,度 (TUR) 和酸指数 (PI) 之间的相关性.
主要方法:
- 在过和未过的水样本中分析了26个PhAC.
- 使用纸张,1微米玻璃微纤维和0.45微米尼龙过器进行过.
- 度 (TUR) 和 permanganate 指数 (PI) 的确定以评估有机物质含量.
主要成果:
- 在过和未过的废水样本之间的PhAC量化中没有观察到显著差异.
- 对于大多数分析品,PhAC度与度 (TUR) 有正相关性,与酸盐指数 (PI) 有负相关性.
- 过没有导致除目标PhACs,这表明这是一个安全的步骤.
结论:
- 预先过废水样本不会显著影响制药活性化合物 (PhAC) 的量化.
- 过步骤有效地防止SPE弹堵塞,而不会影响分析结果.
- 这些发现支持直接SPE没有预先过作为废水中PhAC分析的可行和潜在更有效的方法.
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