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相关概念视频

Design Example: Measuring Distance Between Two Points with Obstructions01:10

Design Example: Measuring Distance Between Two Points with Obstructions

When measuring distances in areas with physical obstructions, such as a lake in a field, surveyors must employ techniques to calculate accurate lengths without direct line measurements. One effective method is the offset technique, which allows for precise distance estimation over inaccessible stretches.In this scenario, a surveyor must measure a side of an area that crosses a lake. Since the measuring tape cannot span the lake, the surveyor begins by establishing a baseline that aligns with...
Modeling and Similitude01:12

Modeling and Similitude

Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
Typical Model Studies01:30

Typical Model Studies

Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
Methods of Medium Optimization01:28

Methods of Medium Optimization

Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...

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相关实验视频

Updated: Jun 27, 2026

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering
07:47

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering

Published on: September 16, 2016

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使用实验和模拟涂层技术探索涂层设计间距.

Peter Böhling1, Johan Remmelgas1, Daniel To2

  • 1Research Center Pharmaceutical Engineering GmbH, Graz, Austria.

International journal of pharmaceutics
|May 30, 2025
PubMed
概括
此摘要是机器生成的。

计算流体动力学-离散元件方法 (CFD-DEM) 模拟准确建模的平板电脑涂层过程. 这种数字方法通过分析空气流对平板电脑移动和质量分布的影响来优化涂层均性和干燥效率.

关键词:
涂层过程的涂层过程.设计空间 设计空间模拟模拟是为了模拟.平板电脑上的涂层.

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科学领域:

  • 化学工程是化学工程的重要组成部分.
  • 制药科学 制药科学
  • 计算机建模 计算建模

背景情况:

  • 平板电脑涂层对于药物输送和稳定性至关重要.
  • 优化涂层过程需要理解复杂的多相相互作用.
  • 计算流体动力学离散元件方法 (CFD-DEM) 提供了一个强大的模拟工具.

研究的目的:

  • 为了提高对实验室规模的平板电脑涂层工艺的理解.
  • 使用CFD-DEM模拟来建模动量,热量和质量转移.
  • 为了验证模拟结果与实验数据对比.

主要方法:

  • 从实验设计空间中选择了八个过程点.
  • 在使用CFD-DEM的模拟中进行.
  • 分析了平板运动,涂层质量分布,温度和溶剂蒸发.

主要成果:

  • 干燥空气流速显著影响了药片的移动和涂层的均性.
  • 模拟显示变化系数的线性衰变,与实验发现相匹配.
  • 预测的温度与实验值非常相匹配,在更高的温度下有轻微的过度预测.

结论:

  • CFD-DEM模拟有效地将平板电脑涂层实验数字化复制.
  • 这些模型提供了通过数字探索优化涂层过程的见解.
  • 数字模拟有助于更好地理解空气流动动力学和干燥参数.