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Updated: Jun 15, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Published on: July 25, 2013

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基于结构设计的芳香螺旋折叠分子-蛋白质接口

Lingfei Wang1, Céline Douat1, Johannes Sigl1

  • 1Department Pharmazie, Ludwig-Maximilians-Universität München Butenandtstr. 5-13 81377 München Germany ivan.huc@cup.lmu.de.

Chemical science
|June 13, 2025
PubMed
概括

研究人员修改了芳香折叠体,以更好地与人类碳酸无水酶II (HCAII) 相互作用. 虽然修改改进了蛋白质接口接触和螺旋控制,但它们并没有显著增加对HCAII的结合亲和力.

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