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Updated: Sep 15, 2025

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设计一种基于人体的转化激活剂,用于目标蛋白表达恢复

Riley W Sinnott1, Ani Solanki2, Anitha P Govind3

  • 1Department of Chemistry, The University of Chicago, 5735 S. Ellis Ave., Chicago, IL 60637.

bioRxiv : the preprint server for biology
|July 17, 2025
PubMed
概括

这项研究引入了一种新方法来促进像德拉维特综合征这样的疾病的蛋白质生产. 一种新的转化激活剂通过增加SCN1a蛋白水平,在小鼠模型中改善了生存率和减少了发作.

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Conservative Site-specific Recombination and Phase Variation02:53

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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