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Updated: Sep 13, 2025

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合成一个Light-Up探测器与一个Trioxazole骨架跟踪G-四重复动态行为跟踪

Haruki Fujita1, Naruyuki Watatani1, Shogo Sasaki2

  • 1Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.

Analytical chemistry
|July 25, 2025
PubMed
概括

研究人员开发了一种新的光探针,TO-2,3VN (2f),用于跟踪活细胞中的关氨酸四重复 (G4) 动态. 这个探测器可以实时可视化G4的折叠和展开,有助于理解它们的生物作用.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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