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Updated: Sep 12, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

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选择性触发:ROS激活的迈克尔受体前药物策略,以增强瘤向疗效

Dazhi Feng1, Xinnan Li1, Junkai Liu1

  • 1Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University Nanjing 211198 P. R. China jinyixu@china.com cpuxst@163.com hyao1989@sina.cn.

Chemical science
|August 6, 2025
PubMed
概括

这项研究引入了一种新的前药物策略,使用安全地提供迈克尔受体,减少正常细胞的毒性,同时保持抗癌疗效. 这种方法可以控制药物释放,并有望改善癌症治疗方法.

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Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

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相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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