Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Naringenin-functionalized polyester nanoparticles improve oral urolithin A delivery and protect against cisplatin-induced kidney injury via heme oxygenase-1 activation and mitochondrial quality control.

The Journal of pharmacology and experimental therapeutics·2026
Same author

Dual-Ligand Targeted Nanoparticles Enhance In Vitro Delivery and Efficacy of Investigational Drug Candidate GAT211.

ACS applied bio materials·2025
Same author

Design and In Vitro Evaluation of Gambogic Acid-Conjugated Stearic Acid Solid Lipid Nanoparticles for Transferrin Receptor-Mediated Drug Delivery.

Pharmaceutical research·2025
Same author

Establishing PDE4 as a Novel Target of Urolithin-A in Mitigating LPS-induced Inflammation in Retinal Pigmented Epithelium Cells.

Pharmaceutical research·2025
Same author

UPLC-MS/MS Method for Simultaneous Quantification of Cyclosporine A and Urolithin A in Plasma and Interspecies Analysis Across Mammals Including Humans.

ACS omega·2025
Same author

Interplay between Skeletal Muscle Catabolism and Remodeling of Arteriovenous Fistula by Yes-Associated Protein 1 (YAP1) Signaling.

Journal of the American Society of Nephrology : JASN·2025

相关实验视频

Updated: May 1, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

37.5K

双功能聚纳米颗粒用于放大抗炎作用.

Ingrid M Heyns1,2,3, Abiodun T Wahab1,2,3, Raghu Ganugula1,2,3,4

  • 1Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, AL 35401, USA.

Science advances
|August 6, 2025
PubMed
概括

这项研究开发了双重作用的纳米粒子,用于增强肠道药物输送. 这些系统有效地对抗炎症,并减少治疗急性损伤 (AKI) 所需的剂量.

更多相关视频

Procedure for Fabricating Biofunctional Nanofibers
09:39

Procedure for Fabricating Biofunctional Nanofibers

Published on: September 10, 2012

12.7K
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.5K

相关实验视频

Last Updated: May 1, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

37.5K
Procedure for Fabricating Biofunctional Nanofibers
09:39

Procedure for Fabricating Biofunctional Nanofibers

Published on: September 10, 2012

12.7K
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.5K

科学领域:

  • 纳米医学是一种纳米医学.
  • 药理学 药理学是指药理学的学科.
  • 免疫学 免疫学 免疫学

背景情况:

  • 急性损伤 (AKI) 涉及炎症和纤维化.
  • 纳灵宁 (NAR) 具有抗炎性质,但面临生物可用性挑战.
  • 有针对性的药物输送系统可以提高治疗效率并减少副作用.

研究的目的:

  • 开发和评估双重作用的纳米颗粒,以提高肠道吸收和宁素 (NAR) 的向输送.
  • 研究这些纳米颗粒对抗炎症和治疗西斯胺诱导的AKI的疗效.
  • 评估纳米粒子配方对免疫调节和治疗结果的作用.

主要方法:

  • 使用NAR作为叶酸受体连接体的NAR负载被动纳米颗粒[P2Ns (NAR) ]和双重作用系统[P2Ns-NAR (NAR) ]的配方.
  • 在实验室中对西斯普拉丁诱导的人类脏-2细胞进行测试.
  • 在小鼠模型中对西斯普拉丁诱导的AKI进行体内评估,评估免疫反应,功能,纤维化和分子标记.

主要成果:

  • 两种P2Ns (NAR) 和P2Ns-NAR (NAR) 均表现出与非配方NAR相比的显著优势,有效剂量降低了分别高达57%和79%.
  • 纳米粒子调节了免疫反应,恢复了T细胞功能,并将巨细胞转移到M2表型.
  • P2Ns-NAR显著缓解了AKI,减少了纤维化,降低了Toll样受体4和核因子kB的水平,与其他配方相比,有效剂量降低了50%.

结论:

  • 双重作用的纳米粒子有效地增强肠道吸收和治疗性输送naringenin.
  • 基于naringenin的纳米颗粒通过调节免疫反应和减少组织损伤,在治疗AKI等炎症性疾病方面显示出显著的潜力.
  • 聚合物功能对于开发有效的药物输送系统至关重要,这些系统可以克服生物障碍并改善治疗结果.