Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.5K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.5K
Chemotaxis in E. coli01:27

Chemotaxis in E. coli

97
Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...
97
Neural Regulation01:37

Neural Regulation

40.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.0K
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

759
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
759
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

401
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
401
Parasympathetic Signaling01:30

Parasympathetic Signaling

2.2K
Parasympathetic signaling plays a crucial role in regulating various physiological processes. It involves the release of acetylcholine (ACh) by parasympathetic neurons, which can have localized and short-lived effects. The majority of ACh released is rapidly inactivated at the synapse by the enzyme acetylcholinesterase (AChE), which hydrolyzes Ach into choline and acetate. Additionally, the tissue cholinesterase deactivates any ACh diffusing into the surrounding tissues.
The effects of...
2.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Structure and signaling mechanism of <i>Helicobacter pylori</i> transducer-like protein D.

bioRxiv : the preprint server for biology·2026
Same author

Hijacking anaerobic metabolism to restore antibiotic efficacy in <i>Pseudomonas aeruginosa</i>.

Applied and environmental microbiology·2025
Same author

AlphaFold 3 accurately models natural variants of <i>Helicobacter pylori</i> catalase KatA.

Microbiology spectrum·2025
Same author

Applying Computational Protein Design to Engineer Affibodies for Affinity-controlled Delivery of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor.

Biomacromolecules·2025
Same author

Zebrafish do not have a calprotectin ortholog.

PloS one·2025
Same author

Changing expression system alters oligomerization and proinflammatory activity of recombinant human S100A9.

bioRxiv : the preprint server for biology·2024

相关实验视频

Updated: Sep 11, 2025

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
10:40

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation

Published on: November 9, 2017

7.1K

在肠道化疗刺激中的矛盾导航.

Kailie Franco1, Zealon Gentry-Lear2, Michael Shavlik3

  • 1Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, United States.

eLife
|August 11, 2025
PubMed
概括

细菌对印的化学作用是复杂的;而纯粹的印会驱逐病原体,便物通过Tsr受体吸引它们,覆盖排斥并帮助病原体在肠道中存活.

关键词:
这是一种Citrobacter koseri.美国大肠杆菌 (E. coli).肠杆菌cloacaee是什么意思埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.沙门氏菌进入Typhimurium类型.传染病是一种传染性疾病.微生物学的微生物.微生物组是一个微生物组.分子生物物理学分子生物物理学结构生物学结构生物学

更多相关视频

A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients
09:28

A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients

Published on: April 19, 2010

12.3K
Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
09:40

Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

18.1K

相关实验视频

Last Updated: Sep 11, 2025

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
10:40

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation

Published on: November 9, 2017

7.1K
A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients
09:28

A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients

Published on: April 19, 2010

12.3K
Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
09:40

Imaging G-protein Coupled Receptor GPCR-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

18.1K

科学领域:

  • 微生物学 微生物学
  • 细菌化学反应 (Bacterial Chemotaxis) 是一种
  • 宿主-病原体相互作用

背景情况:

  • 肠杆菌利用化学反应和Tsr化学受体进行营养感应.
  • 作为肠道微生物群的产物,Indole被假设作为一种化学排斥剂,保护宿主免受病原体的侵害.
  • 便含有复杂的化学吸引剂和化学排斥剂信号,包括.

研究的目的:

  • 为了研究 Tsr 化学受体在介导细菌化学排斥的作用.
  • 为了确定其自然环境 (便) 中的英多尔是否足以进行病原体化学排斥和宿主保护.
  • 了解便中的竞争性化疗因子如何影响细菌对内的反应.

主要方法:

  • 利用肠道爆炸系统研究细菌化学反应.
  • 采用实时成像来观察细菌的行为,以应对纯的内和便物质.
  • 研究了各种肠杆菌菌种的保存反应,其中包括 Tsr 的 orthologues.

主要成果:

  • 纯醇通过化学反应抑制了沙门氏菌Typhimurium的感染优势.
  • 这种以醇为媒介的抑制被其他便化学效应物,如L-氨酸 (L-Ser) 取决于Tsr.取消.
  • 沙门氏菌 Typhimurium 强烈地被人类便所吸引,尽管含有高的英多尔含量,但通过 Tsr 传感英多尔和吸引剂.
  • 由 Tsr 介导的便吸引力在各种 Enterobacteriaceae 中保持,包括 E. coli.
  • 像L-Ser这样的便化学吸引剂会覆盖醇化学排斥,醇水平调节吸引力大小.

结论:

  • 印度尔诱导的化学排斥不能保护肠道感染,并且通过促进位定位,可能有利于病原体.
  • 在自然环境中的细菌化学反应是由多个,通常是相反的化学信号的整合形成的.
  • 单因子研究可能无法准确预测肠道等复杂的生物矩阵中的细菌行为.