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Updated: Sep 9, 2025

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在渐进的多发性硬化症中,质纤维酸蛋白升高

Luke A Schwerdtfeger1, Federico Montini1,2, Martina Antonini Cencicchio2

  • 1Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Neurology(R) neuroimmunology & neuroinflammation
|August 28, 2025
PubMed
概括

在渐进的多发性硬化症患者中发现了质纤维酸蛋白 (GFAP) 的较高水平,这表明它可能是疾病恶化的预后生物标志物.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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