用可注射生物相容激活器官凝长期治疗关节炎
Chengbiao Ding1,2,3, Zhenyu Liu1,2, Lin Mei4,5
1Department of Rehabilitation Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
ACS omega
|September 2, 2025
概括
这项研究引入了用于治疗类风湿性关节炎 (RA) 的可注射水凝,增强素的作用.
科学领域:
- 生物材料科学
- 药物输送系统
- 关节病学
背景情况:
- 类风湿性关节炎 (RA) 是一种自身免疫性疾病,导致关节损伤和行动能力丧失.
- Quercetin 是一种天然化合物,具有 RA 治疗的潜力,但其生物可用性和安全性不佳.
- 现有的治疗方法往往在有效性和副作用方面存在局限性.
研究的目的:
- 开发一种可注射的新型水凝系统,用于针对性地向RA关节输送激活素.
- 通过低温大气等离子体 (LTAP) 激活方法增强素的治疗效果和安全性.
- 评估开发的水凝在缓解RA关节破坏和炎症方面的 in vivo 疗效.
主要方法:
- 使用低温大气等离子体 (LTAP) 激活奎尔素成原酸.
- 通过动态合激活素与波洛克萨默和藻酸盐来制备可注射凝.
- 在风湿性关节炎模型中对水凝的疗效进行体内评估,评估骨破坏,骨形成和炎症标志物.
主要成果:
- 与单独使用氨酸相比,用LTAP激活的氨酸水凝显示出更好的安全性,吸收和新陈代谢.
- 在体内,局部注射水凝有效降低了骨破坏,并抑制了骨形成.
- 水凝显著抑制了关键的炎症因素,包括IL-6,IL-1β和TNF-α.
结论:
- 开发的可注射水凝系统为风湿性关节炎提供了有前途的向药物输送方法.
- 激活LTAP增强了奎尔塞丁对RA的治疗潜力,克服了原生化合物的局限性.
- 这种新的水凝配方有效地保护关节,减少RA的炎症和结构损伤.
相关概念视频
01:26Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
2.2K
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
The binding of dantrolene to the RYR1...
2.2K
01:31Skeletal Muscle Relaxants: Therapeutic Uses
1.2K
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
1.2K
01:24Centrally Acting Muscle Relaxants: Therapeutic Uses
1.7K
Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
1.7K
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
755
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
755
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
880
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
880
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
692
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
692