BrainProt v3.0:关于人类大脑及其相关疾病的综合和简化的基于Omics的知识库
Deeptarup Biswas1, Sanjyot Vinayak Shenoy2, Aparna Chauhan1
1Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Journal of proteome research
|September 26, 2025
概括
BrainProt v3.0 是人类大脑疾病的新知识库,集成omics数据以识别疾病标志物和药物标. 这个资源通过整合分散的数据来帮助神经科学研究,推动人类大脑蛋白质组项目.
科学领域:
- 神经科学是一个神经科学.
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 神经科学研究产生了大量关于大脑疾病的数据,这些数据通常分散在各种存储库中.
- 这种数据碎片化阻碍了全球理解和治疗神经系统疾病的努力.
- 奥米克技术提供了深刻的生物学见解,但需要集成的平台来进行有效的分析.
研究的目的:
- 为了介绍BrainProt v3.0,一个对人类大脑疾病的奥米克驱动的知识库.
- 整合多样化的数据集,包括基因,化学相互作用,临床试验和多组数据.
- 为了促进生物交叉交谈的探索和识别关键疾病标志物.
主要方法:
- 开发和整合人类大脑疾病图谱 (HBDA),大脑疾病标记器策划器 (BDMC) 和大脑疾病药物寻找器 (BDDF).
- 通过大脑疾病转录组图 (BDTM) 和大脑疾病蛋白质组图 (BDPM) 对重大脑病的多组数据 (转录组和蛋白质组) 的汇编.
- 分析了52个数据集和1868个样本,以显示表达特征和确定相关性.
主要成果:
- BrainProt v3.0包含了20202个与疾病相关的基因和136,557个化学向相互作用.
- 该平台包括2,145个临床试验细节,并对主要大脑疾病的多组数据进行整理.
- 促进对转录组和蛋白组数据相关性的探索,以识别疾病标志物.
结论:
- BrainProt v3.0通过增强对大脑疾病的数据集成来推进人类大脑蛋白质组项目 (HBPP).
- 该平台有助于阐明大脑疾病及其相关标志物的复杂性.
- 支持研究大脑瘤和神经退行性疾病之间的相互作用.
相关概念视频
Organization of the Brain
2.3K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.3K
Cerebral Hemispheres
2.0K
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
2.0K
Brain Imaging
667
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
667
Introduction to Biological Bases of Psychology
4.4K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
The nervous system, the cornerstone of...
4.4K
Anatomy of the Brain: Major Regions
9.8K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
9.8K
Cerebrum: Anatomical Overview I
4.8K
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
4.8K


