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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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全组织转录组分析揭示了性别二态的人类衰老.

Siqi Wang1,2, Danyue Dong1, Xin Li1

  • 1Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

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概括

这项研究揭示了35个人类组织中衰老的显著性别差异,影响基因表达和替代拼接 (AS). 男性的衰老显示早期,更大的转录组变化与性激素和阿尔茨海默病风险有关.

关键词:
附加的监管网络 附加的监管网络老化的老化 衰老的老化另一个替代拼接方法是拼接.染色体是一种染色体.计算生物学是计算生物学.基因表达的基因表达方式人类 人类 人类 人类 人类 人类 人类两性二态性质的性别二态性系统生物学 系统生物学时间序列时间序列

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科学领域:

  • 基因组学就是基因组学.
  • 衰老研究研究 衰老研究
  • 医学中的性别差异.

背景情况:

  • 复杂的疾病在结果中表现出性别二态,通常与衰老有关.
  • 跨多种组织的性别二态衰老机制尚不清楚.

研究的目的:

  • 量化评估性别和年龄对35个人类组织的转录组变异的贡献.
  • 揭示了性别二态衰老模式背后的分子机制.

主要方法:

  • 从35个人体组织中对约17.000个转录组进行了系统分析.
  • 基因表达和替代拼接 (AS) 变化与性别和年龄相关的评估.
  • 断点分析将衰老速度与性激素水平联系起来.

主要成果:

  • 在老化转录组中观察到广泛的两性二态,具有基因表达和AS的独特模式.
  • 男性偏差与年龄相关的AS事件与阿尔茨海默病风险相关.
  • 女性偏见的AS事件可能由雌激素受体通路调节.
  • 性质变态衰老率与性激素下降有关;男性表现得更早,更明显的转录组变化.

结论:

  • 性在分子和多组织层面上在衰老中起着至关重要的作用.
  • 已识别的两性调节模式为与年龄相关的疾病提供了洞察力.
  • 研究结果强调了在衰老研究和临床应用中考虑性别的重要性.