克罗恩氏病紧张症:多模式成像识别成像生物标志物
Safa Hoodeshenas1, Jonathan R Dillman1, Stuart A Taylor1
1From the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).
克朗氏病 (CD) 小肠狭窄的成像生物标志物有助于诊断和外科风险评估. 新的定量生物标志物显示出评估纤维化和炎症的前景,指导患者管理.
科学领域:
- 胃肠病学 胃肠病学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 克罗恩氏病 (CD) 小肠狭窄导致需要手术的并发症.
- 建立了用于CD收缩的标准化成像功能.
- 精确评估收缩特征对于管理至关重要.
研究的目的:
- 审查和定义CD中小肠狭窄的形态成像特征.
- 突出成像生物标志物在诊断和测量狭窄的作用.
- 讨论新兴的定量生物标志物用于他的病理学相关物和生物机械性质.
主要方法:
- 审查常规的MR和CT肠道学特征.
- 专注于定量成像生物标志物,特别是MRI和美国方法.
- 对反映纤维化,炎症和光滑肌肉增生/增缩的生物标志物的分析.
主要成果:
- 定义了CD小肠狭窄的形态成像特征.
- 图像化生物标志物可以重复诊断和测量狭窄.
- 新兴的生物标志物显示出评估组织病理学和生物机械性能的潜力.
结论:
- 图像检测对于严格治疗CD的患者的管理至关重要.
- 将定义的成像特征纳入报告可以指导管理和临床试验.
- 定量成像生物标志物为精确评估狭窄性构成和性质提供了有希望的途径.
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