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相关概念视频

Lagging Strand Synthesis01:59

Lagging Strand Synthesis

60.8K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
60.8K
The Replisome03:01

The Replisome

38.0K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
38.0K
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

6.2K
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
6.2K
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

2.3K
2.3K
Chromosome Replication02:31

Chromosome Replication

10.4K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
10.4K
DNA Replication02:40

DNA Replication

58.3K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
58.3K

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相关实验视频

Updated: Jan 12, 2026

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
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Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement

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时间势头:在线复制和超越

Manuel Vencato1, Marco Zorzi1,2, Mario Bonato3

  • 1Department of General Psychology and Padova Neuroscience Center, University of Padova, Padova, Italy.

Psychological research
|November 5, 2025
PubMed
概括

心理算术影响时间感知,加法延长感知持续时间,减法缩短时间. 这种时间动量效应是可靠的,并且无论操作顺序如何,都会发生,这表明与空间处理有共同的机制.

科学领域:

  • 认知心理学 认知心理学
  • 神经科学是一个神经科学.
  • 心理物理学的精神物理.

背景情况:

  • 心理算术运算可以扭曲时间的感知.
  • 时间动量,类似于表示动量,描述了特定操作的时间扭曲.
  • 以前的研究表明,加法延长,减法缩短感知时间持续时间.

研究的目的:

  • 用在线数据收集程序复制和验证时间动量效应.
  • 为了调查操作数顺序是否影响减去时的时间动量效应.
  • 在认知任务中探索时间和空间处理之间的关系.

主要方法:

  • 使用在线时间复制范式,直接复制时间算术任务.
  • 实验1:通过在线数据收集评估时间势头的可靠性.
  • 实验2:在减法中操纵操作顺序,以测试其对时间动量的影响.

主要成果:

  • 使用在线程序可靠地复制了时间势头效应,与之前的实验室发现相匹配.
  • 减法中的时间动量即使在操作顺序变化时也持续存在.
  • 结果证实,时间势头不是刺激顺序的工件.

结论:

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  • 时间动量效应是一个强大的现象,指数时间的心理操纵.
  • 运行顺序不考虑在减法中观察到的时间扭曲.
  • 时间感知与空间表示共享处理特征,支持统一的认知架构.