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Updated: Jan 11, 2026

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识别合理敏感性分析的策略 使用PBPK建模来预测沉性药物相互作用的药物相互作用.

Kunal S Taskar1, Pradeep Sharma2, Karen Rowland Yeo3

  • 1Drug Metabolism and Pharmacokinetics, Research Technologies, GSK, Stevenage, UK.

Clinical pharmacology and therapeutics
|November 13, 2025
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模有助于药物相互作用 (DDI) 的预测. 这种观点倡导PBPK-DDI评估的实用灵敏度分析 (SA) 方法,以提高临床相关性.

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