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相关概念视频

Numerical Calculations01:24

Numerical Calculations

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In engineering applications, the representation of the numerical value is critical. Presenting or reporting the answer is one of the essential parts of engineering practices. Numerical calculations are performed using handheld calculators or computers since numerically accurate answers are always preferred.
The solution to a problem is obtained using different methods. While manually solving algebraic symbols is one of the most common methods, the graphical method is often preferred. Computers...
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The Squeeze Theorem01:30

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Certain mathematical functions exhibit unpredictable or highly variable behavior near specific input values, making direct evaluation of their limits challenging. This complexity may arise from rapid oscillations or irregular patterns that obscure the function’s trend. In such cases, the Squeeze Theorem offers a reliable method for determining limits.According to the Squeeze Theorem, if a function is confined between two other functions near a particular point, and both outer functions...
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相关实验视频

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Direct Pressure Monitoring Accurately Predicts Pulmonary Vein Occlusion During Cryoballoon Ablation
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数字模拟和实验验证多探针冷缩的数值模拟.

Jian Zhang1, Bei Tong1, Changmao Ni1

  • 1Wuhan Neuracom Technology Development Co., Ltd., Wuhan 430073, China.

Micromachines
|December 31, 2025
PubMed
概括

这项研究验证了一个冷化模型,用于预测冰球形状和优化探头布局. 虽然它对于热场是准确的,但它强调了需要将时间-温度效应纳入精确的生物损害预测的必要性.

科学领域:

  • 生物医学工程 生物医学工程
  • 医学物理 医学物理
  • 热力工程是热力工程中的一个.

背景情况:

  • 结冷处理是一种微创治疗,使用极度寒冷来破坏不需要的组织.
  • 准确预测冰球的形成和治疗的有效性对于成功的冷处理至关重要.
  • 优化探头放置和理解热场相互作用是多探头冷处理的关键挑战.

研究的目的:

  • 开发和验证一个数值模型,用于预测多探针冷化中的冰球形状和热场.
  • 为了优化冷探针的空间布局,以实现均的冷却.
  • 对实验数据评估模型的预测准确性,并确定预测生物损害的局限性.

主要方法:

  • 开发了使用Pennes生物热方程与相变的多探针冷化3D数值模型.
  • 通过将模拟的温度概况和冰球形状与实验测量进行比较来验证模型.
  • 研究了不同的探头布局,以确定为产生均热场的最佳间距.
  • 对猪肝组织进行了组织学分析,以比较预测的损伤与观察到的生物效应.

主要成果:

  • 该数值模型准确地预测了温度配置文件和冰球形状,冰球尺寸的平均误差为3.75%.
  • 以1厘米间隔的9探头布局被认为是创建统一的低温场的最佳方案.
关键词:
结冷除法 结冷除法通过ex vivo验证进行验证.多探头布局的布局.数字模拟的数字模拟.

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  • 组织学分析显示了预测和实际的生物损伤区域之间的差异,表明稳定状态模型的局限性.

    • 结论:

    • 经过验证的热物理模型作为一个有价值的工具,用于预手术规划在冷.
    • 准确预测生物损伤需要将时间-温度剂量效应纳入简单的临界温度值之外.
    • 未来的模型应该整合热剂量计算,以弥合物理模拟和生物结果之间的差距,提高冷处理的精度.